Bio Kratom has a strong effect on your anxiety, mood and energy levels. It lowers your anxiety level, while the feeling has been described as happy, strong, and active, with a strong desire to do work. The mind is described as calm. Thai workers use it to get through a hard day of work. Effects come on within five to ten minutes after use, and can last for several hours. Most people describe the effects as stimulating and euphoric at lower doses, becoming sedative at higher doses. This is probably explained by the fact that mitragynine stimulates the delta opioid receptors when used in small quantities, but tends to increasingly stimulate mu opioid receptors when used in larger quantities. These are the same receptors that are stimulated when using opiate drugs. Bali: Users report that Bali kratom becomes narcotic and very relaxing at higher doses, while it allows for a more stimulating effect when low doses are ingested.