Since its late 1970s debut, Skunk #1 has spawned a plethora of Skunk hybrids that have shaped cannabis worldwide. It remains one of the most famous strains of all time. Skunk #1 is true to its name: a skunky smell with a taste of sour and earthy flavors. This indica-dominant hybrid delivers a high-energy cerebral buzz coupled with deep body relaxation. Skunk #1 is used to treat anxiety and other mental disorders, as well as chronic pain, headaches, and lack of appetite.